Current concepts on anti-Phospholipase A2 receptor antibody in Idiopathic membranous nephropathy
نویسنده
چکیده
Implication for health policy/practice/research/medical education: Phospholipase A2 receptor, is normally expressed in podocyte membrane. In fact the phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a number of biological responses produced by secretory phospholipase A2s (sPLA2s). Determining anti-PLA2r serum levels in patients with nephrotic syndrome should designate a probable diagnosis of idiopathic membranous nephropathy and in patients in which idiopathic membranous nephropathy had a pathology confirmation may be a determining factor to exclude secondary forms of the disease. However, it is too early to abandon a kidney biopsy in patients with nephritic syndrome, and PLA2R as the newly introduced serologic study needs confirmations to finds its proper place in the field of clinical medicine. A R T I C L E I N F O
منابع مشابه
Anti-phospholipase A2 receptor antibody in membranous nephropathy.
The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV)-associated MN, and 10 with tumor-associated ...
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Objectives: This study was to investigate the effects of anti-M-type phospholipase A2 receptor (PLA2R) antibody in diagnosing and monitoring the progresssion in idiopathic membranous nephropathy (iMN). Methods: Fifty-six cases with iMN were chosen from October 2009 to November 2015. The control cohorts were patients with hepatitis B virus associated MN (n=17), lupus nephritis related MN (n=19) ...
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The data were presented in abstract form at the 45(th) meeting of the American Society of Nephrology, October 30-November 04 2012, San Diego, CA, USA. Circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R) are important pathogenic antibodies of idiopathic membranous nephropathy (MN) in adults. However, previous studies on the clinical impact of anti-PLA2R antibodies demonst...
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